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Accutane and Liver Damage

WARNING: Clinical hepatitis considered to be possibly or probably related to Accutane therapy has been reported. Additionally, mile to moderate elevations of liver enzymes have been observed in approximately 15% of individuals treated during clinical trials, some of which normalized with dosage reduction or continued administration of the drug. If normalization does not readily occur or if hepatitis is suspected during treatment with Accutane, the drug should be discontinued and the etiology further investigated.

Acute and chronic liver diseases can interfere with the proper functions of the liver and cause symptoms. However, the liver is a strong organ and it usually takes a substantial amount of damage before the disease interferes with the liver?s functions and causes symptoms. If you have any liver problems or history of liver problems in your family, you should let your physician know before making the decision to begin Accutane treatment.

Some diseases of the liver caused by Accutane include:

Hepatotoxicity - a state of toxic damage to the liver

Hepatitis - on going injury to the cells of the liver with inflammation. Causes of Hepatitis include viruses, abnormalities and medications

Cirrhoses - a group of chronic liver diseases in which normal liver cells are damaged and replaced by scar tissue. This decreases the amount of normal liver tissue and the liver's ability to function properly.

Fatty Liver - an accumulation of fat cells in the liver

Symptoms of liver damage or diseases include:

Upper abdominal discomfort

Jaundice

Bleeding or easy bruising

Swelling of the legs

Fatigue

Loss of Appetite

Aching joints

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Have you or loved one used Accutane® or Generic Isotretinoin?

Have you or loved one been MEDICALLY DIAGNOSED BY A DOCTOR with any of the following conditions within 5 years of using Accutane®?

Symptoms of IBD/IBS with no medical diagnosis

Irritable Bowel Syndrome (IBS)

Inflammatory Bowel Disease (IBD)

Ulcerative Colitis

Crohn's Disease

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Accutane and Liver Damage

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