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Health Canada has ordered that Adderall XR should be questioned and possibly taken off the shelves. They have learned that it has been linked to 20 sudden deaths and 12 strokes. None of the deaths or strokes associated with Adderall XR were reported in Canada, said department spokesman Ryan Baker. "However, Health Canada has received eight reports of adverse reactions ranging in severity from convulsions to minor skin rash,'' Baker said. People taking related ADHD drugs should not stop their treatment but could consult their doctors if they have concerns, the department said."It's not been determined yet whether these reactions were a result of Adderall XR use.''

Shire's chief executive, Matthew Emmens, said in a statement late Wednesday that the company "remains confident in the safety and efficacy" of the drug. The company also said it "strongly disagrees with the conclusions drawn by Health Canada.''Of the 20 cases of sudden death linked to the drug, 14 were in children. Two of the 12 strokes were suffered by children taking the drug. The adverse reactions were not associated with overdose, misuse or abuse of the drug, the department said.

Health Canada decided to review the drug's safety data in light of the international reports of adverse reactions. The incidence of serious adverse reactions leading to death was higher in Adderall XR combined than in any other drugs of this class, the release said.

"At this time, FDA cannot conclude that recommended doses of Adderall can cause sudden unexplained death, but is continuing to carefully evaluate these data,'' the agency said on its website.

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